Skip to Content

Upper Limb Spasticity

Upper limb spasticity is a neurological condition that affects movement in the arms and/or hands and occurs most commonly after a stroke or traumatic brain injury. The condition is associated with muscle stiffness, spasms, and inability to perform daily tasks.1 DaxibotulinumtoxinA for Injection is an investigational agent that has not been approved by the FDA.

Not an actual patient


Estimated number of people worldwide who suffer from spasticity.2


Estimated portion of patient population currently receiving treatment.3


Estimated number of people in the U.S. who suffer from upper limb spasticity.2

Botulinum toxin treatment is the standard of care for management of focal upper limb spasticity. Other treatment options include muscle relaxers and antispastic agents, physical therapy, splints, casts, braces, electrical stimulation, or surgery.

The JUNIPER Phase 2 trial evaluating DaxibotulinumtoxinA for Injection for treatment of adult upper limb spasticity is currently underway and the company expects to report topline results in first quarter of 2021.


1. Spasticity. American Association of Neurological Surgeons. Retrieved from: Accessed 9/29/2020

2. What is spasticity? Life with Spasticity. Retrieved from: Accessed 10/09/2020

3. Munin M et al. Methodology of a Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging, 36-Week, Multicenter Trial to Evaluate the Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Upper Limb Spasticity in Adults After Stroke or Traumatic Brain Injury (JUNIPER). Poster presented at 2019 TOXINS. 16-19 January, 2019. Copenhagen, Denmark.

Back to top