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Not actual patients.

Revance’s therapeutic pipeline seeks to bring innovation to multiple indications in muscle movement and pain disorders.

DaxibotulinumtoxinA for Injection is an investigational agent that has not been approved by the FDA.

Therapeutics

FACTS, FIGURES, & TRENDS

$2.3 billion

Estimated global sales of neurotoxin for therapeutic use.1

12

Approved therapeutic indications for botulinum toxin Type A in the U.S. and hundreds of potential indications.1,2

2

Ongoing clinical trials for therapeutic indications of DaxibotulinumtoxinA for Injection.3,4

DaxibotulinumtoxinA for Injection is an investigational agent that has not been approved by the FDA.

Daring to Make a Difference in Therapeutics

Our investigational neuromodulator product DaxibotulinumtoxinA for Injection is being evaluated in therapeutic indications, including  cervical dystonia (Phase 3) and upper limb spasticity (Phase 2) and has been evaluated in plantar fasciitis (Phase 2). Topline positive results for the cervical dystonia trial ASPEN-1 were announced in October 2020 and represent the first positive Phase 3 trial in the therapeutic neuromodulator category for Revance.​​

For the latest information regarding our clinical development programs, please see our public filings with the Securities and Exchange Commissions or visit www.clinicaltrials.gov.

Not an actual patient.

Cervical Dystonia

Positive topline results from Revance's pivotal ASPEN-1 Phase 3 clinical trial evaluating DaxibotulinumtoxinA for Injection for the treatment of cervical dystonia, a debilitating neurologic disorder affecting the neck muscles, were announced in October 2020. The results demonstrate a potential advancement in the treatment paradigm for patients affected by cervical dystonia. The ASPEN-OLS Phase 3 open-label, long-term safety study results are expected in 2021.

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Adult Upper Limb Spasticity

The JUNIPER Phase 2 Trial for treatment of adult upper limb spasticity is currently underway. Upper limb spasticity is a neurologic condition, usually resulting from stroke, spinal cord injury or multiple sclerosis, that presents as increased tone or stiffness of the muscles affecting a patient's ability to produce or control voluntary movement in the arms and hands. Revance expects to report topline results from the JUNIPER trial in first quarter of 2021.

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Plantar Fasciitis

Plantar fasciitis is characterized by inflammation and sharp, constant pain in the heel that can become incapacitating. Results from the Phase 2 placebo-controlled clinical trial of DaxibotulinumtoxinA for Injection for the management of plantar fasciitis were announced in November 2020. Revance plans to analyze the data further for additional insights, however our primary focus will be on neuromodulator indications, where the market and path to approval are well established.

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Migraine

Revance is also considering studying DaxibotulinumtoxinA for Injection for migraines. Potential timing of clinical studies is currently being evaluated.

Therapeutics Clinical Program Update

  • PRECLINICAL
  • PHASE 1
  • PHASE 2
  • PHASE 3

DaxibotulinumtoxinA for Injection — Therapeutics

Cervical Dystonia
PHASE 3 COMPLETE
Plantar Fasciitis
IN PHASE 2
Upper Limb Spasticity
IN PHASE 2
ASPEN-OLS Readout in 2021 *Reported results in Nov 2020 Readout in Early 2021

*Revance is continuing to evaluate next steps in plantar fasciitis

Publications

DaxibotulinumtoxinA for Injection is an investigational product. It is currently undergoing clinical studies for both therapeutic and aesthetic indications.

Learn More About Cervical Dystonia with Dr. Joseph Jankovic
  • Learn More About Cervical Dystonia with Dr. Joseph Jankovic
Revance Announces Top-Line Results for ASPEN-1
  • Revance Announces Top-Line Results for ASPEN-1

References

  1. 2019 (E) based on Decision Resources Group Therapeutic Botulinum Toxin Market Analysis Global 2019, November 2018

  2. Time Magazine, January 16, 2017, How BOTOX Became the Drug That’s Treating Everything. Available at: https://time.com/4623409/botox-drug-treating-everything/. Accessed April 2020

  3. Clinicaltrials.gov. US National Library of Medicine. Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity (JUNIPER). Available at: https://clinicaltrials.gov/ct2/show/NCT03821402. Accessed July 2019.

  4. Clinicaltrials.gov. US National Library of Medicine. Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1) (ASPEN-1) Available at: https://clinicaltrials.gov/ct2/show/NCT03608397. Accessed July 2019.

Career Opportunities

Do you have what it takes to join our team? Check out our Careers page and find out.

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